2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-111664
    (R)-(+)-Citronellal 2385-77-5
    (R)-(+)-Citronellal, isolated from citrus, lavender and eucalyptus oils, is a monoterpenoid and main component of citronellal oil with a distinct lemon scent. A flavouring agent. Used for insect repellent and antifungal properties.
    (R)-(+)-Citronellal
  • HY-112257
    S-23 1010396-29-8 99.93%
    S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
    S-23
  • HY-112619
    TES-991 1883602-20-7 99.65%
    TES-991 is a potent and selective human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC50 of 3 nM.
    TES-991
  • HY-113020
    21-Hydroxypregnenolone 1164-98-3 98.75%
    21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis.
    21-Hydroxypregnenolone
  • HY-113075
    1,5-Anhydrosorbitol 154-58-5 ≥98.0%
    1,5-Anhydrosorbitol is a short-term marker for glycemic control.
    1,5-Anhydrosorbitol
  • HY-113138
    3-Methyluridine 2140-69-4 99.05%
    3-Methyluridine (m3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance.
    3-Methyluridine
  • HY-113315
    3b-Hydroxy-5-cholenoic acid 5255-17-4 ≥99.0%
    3b-Hydroxy-5-cholenoic acid is a monohydroxy bile acid of endogenous origin. 3b-Hydroxy-5-cholenoic acid can be used in the study of hepatic ductular hypoplasia syndrome.
    3b-Hydroxy-5-cholenoic acid
  • HY-120332
    Sonlicromanol hydrochloride 2162149-24-6 99.85%
    Sonlicromanol (KH176) hydrochloride, a chemical entity derivative of Trolox, is a blood-brain barrier permeable ROS-redox modulator. Sonlicromanol (KH176) hydrochloride is used in the study for mitochondrial disorders.
    Sonlicromanol hydrochloride
  • HY-123672
    Lovastatin hydroxy acid sodium 75225-50-2 ≥99.0%
    Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM.
    Lovastatin hydroxy acid sodium
  • HY-124822
    COH-SR4 73439-19-7 99.45%
    COH-SR4 is an AMPK activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders.
    COH-SR4
  • HY-125130
    Hesperetin 7-O-glucoside 31712-49-9 98.08%
    Hesperetin 7-O-glucoside is a typical flavonoid monoglucoside, which is an anti-inflammatory agent and an antihypertensive with orally active. Hesperetin 7-O-glucoside is a commonly used food adjuvant. Hesperetin 7-O-glucoside inhibits human intestinal maltase and human HMG-CoA reductase with Ki of 1.8 mM and 9.8 μM, respectively. Hesperetin 7-O-glucoside has antibacterial activity and can regulate intestinal flora and metabolic homeostasis in mice.
    Hesperetin 7-O-glucoside
  • HY-125556
    Tetragastrin 1947-37-1 99.60%
    Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) is the C-terminal tetrapeptide of gastrin. Tetragastrin can stimulate gastric secretion. Tetragastrin is a Cholecystokinin (CCK-4) receptor agonist. Gastric mucosal protection.
    Tetragastrin
  • HY-12717A
    Phentolamine hydrochloride 73-05-2 99.87%
    Phentolamine hydrochloride is an orally active adrenergic α receptor-blocking agent.
    Phentolamine hydrochloride
  • HY-129566
    Withanolide B 56973-41-2 ≥99.0%
    Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects.
    Withanolide B
  • HY-129834
    Bilirubin Conjugate disodium 68683-34-1
    Bilirubin Conjugate disodium is a ditaurate derivative of Bilirubin. Bilirubin, a major end product of heme breakdown, is an important constituent of bile.
    Bilirubin Conjugate disodium
  • HY-132613
    Lumasiran sodium 1834612-06-4 99.21%
    Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .
    Lumasiran sodium
  • HY-133108
    Azadirachtin B 106500-25-8 99.17%
    Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties.
    Azadirachtin B
  • HY-139066
    Punicic acid 544-72-9 ≥98.0%
    Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways.
    Punicic acid
  • HY-147246
    Berberine ursodeoxycholate 1868138-66-2 98.75%
    Berberine ursodeoxycholate (HTD1801), an ionic salt of Berberine and Ursodeoxycholic acid, is an orally active and potent hypolipidemic agent. Berberine ursodeoxycholate shows significantly great reduction in liver fat content. Berberine ursodeoxycholate has a broad spectrum of metabolic activity. Berberine ursodeoxycholate can be used for the research of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes.
    Berberine ursodeoxycholate
  • HY-148349
    PF-07258669 2755890-53-8 98.44%
    PF-07258669 is an orally active melanocortin-4 receptor (MC4R) antagonist that antagonizes MC4R with an IC50 of 13 nM (Ki=0.46 nM). PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa.
    PF-07258669
Cat. No. Product Name / Synonyms Application Reactivity